A new study published November 5th in the Journal of the American Medical Association seems to show that addicted teens that are treated long-term with detoxification medications, including buprenorphine and naloxone, respond better than those treated for a short time. The drugs that were used in this study are two medications that were approved in 2002 by the FDA for the treatment of opioid addiction. Only about 7,000 physicians in the country are registered as potential providers of these drugs, and even less of that number will administer them to young people.

Opiate Detoxification Medications

Buprenorphine is a medication that significantly reduces the cravings of opioids. When combined with naloxone, an opioid antagonist, the results seem to be even better. Naloxone reduces or prevents the effects of drugs such as heroin or prescription painkillers, making them much less desirable to the addict. Naloxone also prevents the patient from misusing the buprenorphine combination because those that would try to inject the drug for a high (instead of taking it orally as prescribed) would suffer severe withdrawal symptoms.

While these medications have been used for adults in many instances, there has been little research on the effectiveness among young people addicted to opioids. The overall number of adolescents that abuse drugs has decreased since 2002, and while this is a very positive trend, the number of painkillers and opioids abused among teens has increased.

Study on Treating Adolescents

Dr. David A. Fiellin of the Yale University School of Medicine reports that as many as 10 percent of ninth graders have used opioids, and that 200,000 to 400,000 adolescents have abused some of these drugs. It seems that drugs are even more readily available to teens today than alcohol, as teens are able to order drugs online or steal them from their parents’ medicine cabinets. Often drug addiction starts as a fun thing that teens try, and ends up as a lifetime of dependence on the substance.

The study done by Dr. George Woody of the University of Pennsylvania’s Department of Psychiatry is one of the first of its kind. As was reported this week, researchers found that those teens that were put on a buprenorphine/naloxone combination (Suboxone) for an extended period of time (12 weeks or longer) were more likely to stay opioid free than those only given the medication for a short period of time. When taken off the medication, the drug use went up. Even with detoxification and counseling, the individuals that were taken off the Suboxone were back to using drugs in a short period of time.
While more research needs to be done on this topic, it seems that Dr. Woody and his team of researchers have shown that Suboxone is an effective treatment in the addiction of opioids when used for an extended period of time. There are those that disagree with the use of drugs to treat drug addiction, but if it means these adolescents have a chance to continue their life free of opioid addiction, many think these more drastic measures are worth taking.

Sources

Reinberg, Steven Extended Therapy Helps Drug-Addicted Teens November 4, 2008

Carver, Alice Extended Therapy for Young Opioid Addicts Better than Short Term Detox, Study November 5, 2008

Opiate Detox

Since 1971, qualified physicians in the United States have been prescribing narcotic medications such as methadone to treat opioid addiction. But this treatment hasn’t come easy, or without its share of debate.

The Methadone Controversy

Russia is one of several countries where methadone is controversial. Recently, members of a Kremlin youth group launched a protest outside a methadone conference, where a group of physicians and specialists were gathered to discuss methadone treatment for drug addictions. In Russia and other countries struggling over this debate, critics of methadone argue that it traps patients in their addictions for life, leaving them addicted to yet another drug.

Methadone is used as a gradual therapy for recovering heroin users, allowing physicians to relieve their patient’s craving for heroin and block the effects of opiates. With methadone, the gradual and mild onset of the “high” prevents users from gaining the pleasurable effects associated with heroin.

However, opponents argue that methadone treatment substitutes one opioid for another, and fear of methadone being sold on the black market is a big concern. Often patients are left struggling with their addiction to methadone, causing their treatment to be lengthy or fail altogether.

In the United States, methadone treatment has become more regulated and widespread in recent years. An individual’s methadone treatment is often viewed as treatment for a disease rather than a poor moral choice. Therefore, treatment may continue throughout the patient’s life, allowing their bodies to be maintained with methadone and avoiding the symptoms of withdrawal altogether. While not a complete solution for a drug free life, methadone treatment has been found to decrease heroin related deaths and crime, and help individuals achieve greater control of their lives.

Buprenorphine and Suboxone

Today a new opioid medication is making its way into treatment facilities, doctor’s offices, and even homes. Buprenorphine is a partial opioid agonist, which causes it to be less addictive than either heroin or methadone. The “high” produced by buprenorphine is less intense, and the side effects are less dangerous. In general, buprenorphine is safer than methadone, and it is easier for a patient to discontinue buprenorphine than to detox from methadone. The NIDA views buprenorphine as a safer, more acceptable maintenance drug than methadone for the treatment of heroin addiction.

A form of buprenorphine, Suboxone, has been rapidly gaining approval for the treatment of opiates. Suboxone contains buprenorphine and naloxone, an opioid antagonist which is to be taken orally. As long as it is taken by mouth as prescribed, the naloxone causes no side effects. If a user would dissolve the Suboxone and inject it in order to get high, the injected naloxone would cause sever withdrawal symptoms. This special formulation of buprenorphine and naloxone is considered safer than just buprenorphine because it so strongly discourages misuse.

The future of drug addiction treatment with Suboxone looks promising. With the support of the NIDA and the SAMHSA, and with further testing, there is hope that in the future this will be a widespread, successful treatment for drug addiction in the United States and other countries.

1. Schwirtz, Michael, Russia Scorns Methadone for Heroin Addiction The New York Times July 22, 2008
2. Blaine, Jack D., Buprenorphine: An Alternative Treatment for Opioid Dependence NIDA Research Monograph, Number 121, 1992
3. National Institute on Drug Abuse, 1999. Principles of Drug Abuse Treatment: A Research-Based Guide. NIH Publication No. 99-4180.
4. Marion, Ira J., Methadone Treatment at 40 Science and Practice Perspectives December 2005
5. Wunsch, Martha Buprenorphine: Balancing Access with Quality of Care (NIH) February 2008
6. Condon, Timothy P., and Clark, Wesley Buprenorphine in the Treatment of Opioid Addiction: Balancing Medication Access with Quality Care (NIH) February 2008